Micky van de Ven Double Halts The Toffees' Run at New Stadium
The Dutch defender emerged as the first backline player to net two goals in a English top-flight game for Spurs since the Belgian defender in March 2013.
Key points
The Spurs defender heads home two times in opening period
Everton's Jake O'Brien has equalizer disallowed after video check
Senegalese midfielder nets third in 89th minute
The defeat is Everton's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs prolonged their winning streak on the road in the top division and handed Everton their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after 133 years at the end of the previous campaign.
But Tottenham's leader Van de Ven pounced twice from set-pieces in the first half to place their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - assisted by ex-Everton forward the Brazilian - headed home a third to seal the victory.
The Everton defender believed he had levelled the tally a short while after Van de Ven's first goal, glancing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, missed a handful of opportunities, while Vicario made a succession of fine stops to ensure the London club went five matches on the road unbeaten in the Premier League.
But the VAR stepped in, instructing Craig Pawson to review the goal on the pitchside monitor and the official decided that the winger and Iliman Ndiaye were in an illegal position and had interfered with the Tottenham goalkeeper.
The win elevates Thomas Frank's team up to third in the division, five points off north London rivals and table-toppers the Gunners.
The Merseyside club remain in 14th position and sit six points ahead of the drop zone.
Spurs breakdown: Van de Ven excels in duties at both ends of the field
Following a drab midweek performance in the Champions League against Monaco, where they managed a only attempts on goal, the manager opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The new arrival was unable to make much of an impact before being replaced for the substitute after an hour on the field, but it turns out he wasn't needed in the end.
Defender Van de Ven converted into an offensive threat to be reckoned with.
Spurs' opening strike came from a cleverly executed corner routine, with the midfielder heading the ball back across the face of goal for an free Van de Ven to score.
And the captain - filling in as captain in Cristian Romero's unavailability - notched his next goal in first-half stoppage time as he outjumped the England keeper to nod in.
Van de Ven was equally outstanding in defensive duties, combining well with Kevin Danso as the pair dealt superbly with the 34 crosses sent their way by the opposition.
Everton analysis: Toffees missing striker's instinct
The club's new home had been a happy hunting ground, but it seems the freshness may have worn off slightly and supporters headed to the gates after the midfielder's final goal for Spurs.
The break in Everton's winning streak at home will not be a massive concern for the manager, but their striker situation are.
Beto and Thierno Barry - the Toffees' pair of established strikers - had scored just a single goal combined before Sunday's outing.
And they were unable to contribute to that miserable tally on a damp and dreary night on in Liverpool.
The striker's form was summed up when he chose to bicycle-kick a clear chance from near the goal, even with having room and time to readjust for a simpler attempt that would have challenged Vicario.
The substitute, as well, was unable to influence the game after replacing the starter in the 65th minute.
It was not for a lack of opportunity. The majority of the home side's offensive moves came through the winger and the forward, who relentlessly whipped threatening balls into the Tottenham penalty area.
What next for these two sides?
The Toffees: Moyes' men travel to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs go to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.